The Royal Children's Hospital Melbourne. Anaesthesia and Pain Management Toggle section navigation In this section About us Parent information Pain management Research and publications Teaching, training and employment Intranet resources Contact us. In this section About us Parent information Pain management Research and publications Teaching, training and employment Intranet resources Contact us. Assessment of sensory block. Local anaesthetics work by blocking nerve impulses on sensory, motor and autonomic nerve fibres. The smallest diameter fibres are most sensitive to the effects of local anaesthetics: autonomic fibres will be blocked first then sensory fibres then motor fibres.
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